Technology Licensing Opportunities
McMaster researchers have identified a prostate cancer stem cell (PCSC) biomarker that promotes PC metastasis and thus has the potential to be developed as a predictive marker and/or therapeutic target for aggressive PC.
McMaster researchers have developed a method of preparing monodisperse degradable gel-based nanoparticles based on thermoresponsive polymers (e.g. poly(N-isopropylacryalmide), PNIPAM, or poly(oligoethylene glycol methacrylate, POEGMA)) for use in a wide range of medical and other applications.
Microvesicles and exosomes are small vesicles released by the cells into their environment. A researcher at McMaster University has discovered that various nuclear receptors can be detected in microvesicles, and transferred from the nucleus of one cell to another using this route of transport. Identified receptors are related to poor prognosis in cancer patients and thus there are implications for this finding in both cancer diagnostics and therapeutics.
Artificial Placenta to Improve Postnatal Gas Exchange in Newborn Infants with Severe Form of Respiratory Failure
The present invention provides compositions and methods for a pumpless, easy-to-use, miniature oxygenation device for neonates.
Capacitive Coupled ECG Sensing Systems: A Minimal Contact and Wearable ECG Sensing Method for Long Term Monitoring
A small, portable and easy to wear ECG system that can monitor patients in the long-term.
Chlamydias are major disease causing agents of infection affecting over 92 million individuals worldwide. McMaster researchers have evaluated novel Chlamydial proteins as immunogens in animal models for their ability to induce a protective immune response.
A compact and portable system using microwave radars to detect concealed weapons.
McMaster researchers have developed a method for the detection and prevention of atherothrombotic disease. This method is based on the discovery that anti-GRP78 autoantibodies in the bloodstream can accelerate atherosclerotic lesion development and increase the activity of tissue factor, the key cellular initiator of blood coagulation.
Non-invasive methods, assays and kits for detecting and monitoring the progress of endometriosis
A new panel of biomarkers that can be used as an early rule-out test for patients presenting with chest pain in the emergency room.
This technology employs electro-erosion to create of a hone radius on the edges of cutting tools for conventional metal cutting operations. It is especially beneficial in the edge preparation of cutting tools made from ultra hard materials such as polycrystalline diamond (PCD).
These hydrogels contain hyaluronic acid hydrogels making them suitable for for ophthalmic applications . For example, contact lenses made of this material will reduce the end of the day, dry eye problem for the wearer.
Identification of CF‐specific biomarkers from blood spot extracts and sweat samples.
A potential biomarkers for cancer diagnosis or a therapeutic target for reducing the risk of cancer and its thrombotic complications
By specifically targeting the OSM-OSM receptor pathway, this novel approach allows slowing/stopping tumour growth in the lungs through regulation of activation or recruitment of non-tumour cells and their products.
McMaster researchers have identified that the combination of salicylate-based drugs, such as Aspirin, with mitochondrial disruptors, can synergistically reduce liver lipid levels and fatty acid synthesis, while improving insulin sensitivity.
This is a novel gene in the process of scar formation in dermal wound healing. A targeted down regulation of this gene by genetic and pharmacological means is expected to prevent scar formation and prevent fibrosis of critical organ systems.
Researchers at McMaster University have developed a method for rapid benchtop fabrication of multi-scale micro-electromagnets for capturing magnetic particles on a lab-on-a-chip (LOC) compatible platform.
Measuring coagulation activation, including thrombin generation, is useful in a number of clinical conditions. McMaster researchers have developed a novel method and class of substrates to do this using whole blood, for instance from a finger prick, using conventional fluorescence equipment.
The invention relates to a new method for monitoring thrombin generation in blood or plasma samples that allows thrombin not bound to A2M to be distinguished from thrombin bound to A2M.